Language

CAS No. 35963-20-3 | (1R)-(-)-10-Camphorsulfonic acid

CAS No. 35963-20-3 | (1R)-(-)-10-Camphorsulfonic acid

Name: (1R)-(-)-10-Camphorsulfonic acid CAS No. 35963-20-3 MF:C10H16O4S MW:232.3 Purity:99% Package: 10g,25g,50g,100g,250g Worldwide Delivery

Categories：

Pharmaceutical Intermediates

Email：sale06@alfachem.cn

Inquiry

Chat Now

Product introduction

Introduction and application of CAS No. 35963-20-3 | (1R)-(-)-10-Camphorsulfonic acid

Synonyms:(-)-CAMPHOR-10-SULPHONICACID;

(-)-CAMPHOR-10-SULFONICACID;

L-(+)-CAMPHORSULFONICACID;

L(+)-CAMPHORSULPHONICACID;

L-CAMPHORSULPHONICACID;(1R)-(-)-CAMPHOR-10-SULPHONICACID;(1R)-(-)-CAMPHORSULFONICACID;(1r)-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulphonicacid

Specification:

ITEMS	SPECIFICATION
CAS	35963-20-3
MF	C10H16O4S
MW	232.3
Melting point	198 °C
Boiling point	344.46°C
Density	1.2981
Acidity coefficient	1.17±0.50
Color	White to slightly beige
Solubility	DMSO (a small amount), methanol (a small amount), water (a small amount)
Form	crystalline powder
Storage condition	Store below +30°C.

Introduction:

Camphorsulfonic acid is produced from camphor through a sulfonation reaction and can be used as a pharmaceutical intermediate and an optically active resolving agent for amino acid drugs. Sodium camphorsulfonate is a central nervous system stimulant for veterinary use and can also be used as a respiratory stimulant. Optically active left- and right-handed camphorsulfonic acid is an important drug resolving agent for chiral isomers. Currently, only the right-handed isomer can be obtained from natural camphor through bromination and sulfonation, while left-handed camphorsulfonic acid needs to be synthesized through synthetic mixture. The spin body is obtained by chemical resolution.

Chemical properties:

L-camphorsulfonic acid is in the form of prismatic crystals with a melting point of 193-195°C (decomposition). [α]D20+24°(water). Slightly soluble in ethanol, glacial acetic acid, ethyl acetate, insoluble in ether, soluble in sodium hydroxide and sodium carbonate solutions. Easily deliquescent in humid air. Used for racemization of optical isomers. It is derived from the reaction of camphor and sulfuric acid. It can be obtained by reacting camphor with sulfuric acid and acetic anhydride. It has the effect of stimulating the respiratory center, vasomotor center and myocardium, and its sodium salt is used medicinally. It is clinically used for acute respiratory and circulatory disorders and to combat central nervous system depressant poisoning.

use:

Organic synthesis intermediates, resolving agents. Used for the racemization and separation of isomer products of pharmaceutical intermediates or optical isomers. The production method is obtained by reacting camphor with sulfuric acid. Add camphor and acetic anhydride to the reaction pot and stir to dissolve. After cooling, add sulfuric acid dropwise and keep the reaction at 44-45°C for 48 hours. Then cool to 6-7°C, crystallize, filter, wash the crystal with a small amount of glacial acetic acid, and dry to obtain camphorsulfonic acid.

Package and transportation :

Package: 10g,25g,50g,100g,250g